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Source: http://repossessedcar.org/how-many-months-behind-before-car-is-repoed/

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Using a technique called ?DNA origami?, US scientists have made programmable molecule-transporting nanorobots that can
seek out particular cell targets and deliver specific instructions for them to follow. One example of such use could be to tell
cancer cells to destroy themselves. The researchers write about their findings in Friday?s online issue of
Science.

The programmable nanorobots carry cargoes of molecules that are released when aptamers (peptide molecules that bind to a
specific target) in their structure bind to specific proteins on the surface of targeted cells.

Researchers at the Wyss Institute for Biologically Inspired Engineering at Harvard University modeled the technology on the
immune system?s white blood cells that patrol the bloodstream, looking for signs of trouble. They hope one day it will be used to
program immune responses to treat diseases.

The DNA origami method is one that folds strands of DNA into complex three-dimensional shapes.

This latest study is considered a breakthrough because it brings together recent advances in DNA origami that have been
pioneered in research centres around the world, not just at the Wyss Institute, to try and meet the challenge of how to kill cancer
cells in a highly selective way.

First author Dr Shawn Douglas, a Wyss Technology Development Fellow when he worked on the study, and colleagues, devised
their nanosized robot in the shape of an open barrel made of two halves joined by a hinge. (Douglas is now an Assistant
Professor in the Faculty of Life Sciences and the Nano-Center at Bar-Ilan University in Israel).

The two halves are held shut by special DNA latches that respond to particular targets by allowing the two halves to swing open
and expose their payload.

The targets the latches respond to are particular combinations of cell-surface proteins: for example these could be disease
markers.

The DNA barrel can contain various payloads. Examples include molecules with specific instructions that receptors on cell
surfaces respond to, causing them to change the signals they send to the cells.

The researchers demonstrated the technology on cells from two types of cancer: leukemia and lymphoma. The message encoded
in the payload was to activate the cells? suicide switch. This triggers a standard feature of all cells, called apoptosis, which allows
aging or abnormal cells to be eliminated.

Leukemia and lymphoma cells don?t speak the same language, so the suicide triggering instructions had to be encoded in different
antibody combinations.

Senior author Dr George Church, a Wyss core faculty member and Professor of Genetics at Harvard Medical School, told the
press:

?We can finally integrate sensing and logical computing functions via complex, yet predictable, nanostructures ? some of the first
hybrids of structural DNA, antibodies, aptamers and metal atomic clusters ? aimed at useful, very specific targeting of human
cancers and T-cells.?

The versatility of the technology emulates that of white blood cells that have the ability to sense a whole range of cell distress
signals, bind to the cells, and then transmit the appropriate self-destruct instructions in the language of that cell
type.

The DNA nanorobot uses modular components to achieve a similar range of versatility: different hinges, different molecular
payloads. These can be switched in and out of the underlying ?chassis?, rather like swapping various engines and tires in and out
of cars.

Such a system should have the potential to treat a variety of diseases. DNA nanotechnology is widely recognized as a potential
way to deliver drugs and molecular signals: another plus is it is biodegradable.

But there are considerable challenges in how to program this tiny machine, never mind how to make the right structure, then get
it to open and close, then re-open, insert, carry and deliver the payload.

The study represents a big step forward in meeting these challenges because three new elements have been combined for the first
time. One of these is because the DNA barrel has no lids, the payloads can be inserted from the side in one step: there is no need
to open and then close the barrel.

The second new element is that this system uses latches that respond to proteins (not DNA or RNA like other systems), which are
commonly found on cell surfaces. And the third new element is that it uses antibody fragments to send the molecular signals, so
by using different combinations of these, different types of immune responses can be replicated to target specific
diseases.

Written by Catharine Paddock PhD

Copyright: Medical News Today

Not to be reproduced without permission of Medical News Today

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Article source: http://www.medicalnewstoday.com/articles/241875.php

Source: http://cancerkick.com/2012/02/19/dna-origami-robots-target-cancer-cells/

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Automobile Loans For Very Terrible Credit Individuals Instruction 5 Steps

Source: http://raynasworldblog.vinelinersworld.com/automobile-loans-for-very-terrible-credit-individuals-instruction-5-steps/

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Higher education can be an education level, moving effectiveness of secondary education in secondary schools, senior high school. Higher education can certainly be sometimes called school teaching as things are in stage or third volume of education ones life.NVQ Health And Social Care
Most people are mindful of the belief that school includes graduate, undergraduate, training and vocational education might also assign specific certifications or equivalent academic qualification.

Education in India is recognized as a great way to bring social understanding people; However, school in India alone represents a primary contradiction. Somewhere from the classroom IITs of India through the best universities around the world, the other side there are plenty of schools which lack even appropriate infrastructure to let students to visit school within a comfortable environment. The structure of education in India is truly the pattern Ten years + Two + Three, the spot that the first a decade, all students must attend general education and will either check out the 2nd phase of 2 years secondary education or training to avoid and go with vocational ends hence the school.nvq level 4 The last phase of three years was named as school in India while in the student?s selection of topic that is referred to as a college education or college education.

Education plays an important role in one?s our life is an ongoing process and keep learning things through the environment or turn to a specific institution to earn an academic degree. We have a growing interest in school worldwide, although it is to pass, have their own benefits, for example interaction with others from different cultures and imparting knowledge directly to them, what?s more, it provides guarantee for a person from finding a secure work and improves the social networks of the baby.

Scholarship for school can be given by individuals, trusts, charities, gov departments or universities the spot that the student applies, a common requirement before receiving these scholarships is definitely the eligibility criteria based on the respective organizations or benefactor have to be satisfied that they will contain mostly age of anyone applying for this academic background, additional activities need to be directed to the actual interest rates are see your face. Scholarships donors can be quite choosy about the student, therefore it is far better to do thorough research to identify a suitable one which has more opportunities for the person chosen.NVQ level 3 Health And Social Care A little but effective tip to assist somebody receive a scholarship as a guaranteed, is usually to find a location that provides a greater quantity of scholarships or more scholarship amount.

This entry was posted in Uncategorized and tagged education. Bookmark the permalink.

Source: http://www.videophile.org/2012/02/20/college-is-education-after-dark-secondary-level/

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AP – Newt Gingrich said Sunday that he and other Republican presidential candidates must win their home-turf contests or face serious questions about continuing in the race.

Source: http://us.rd.yahoo.com/dailynews/rss/gop/*http%3A//news.yahoo.com/s/ap/20120219/ap_on_el_pr/us_gingrich

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Th?n, th?r??s search engine optimisation (SEO), wh??h ?? a very effective Internet marketing strategy. SEO companies through content-based offerings ensure entrepreneurs a high rank ?n th? first page ?f search engines ??k? Google, Yahoo ?n? Bing. SEO companies give fresh ?n? unique articles t? ??t websites achieve th?? high rank. Th??? unique ?n? ?m??rt?nt content ???? n?t ???t guarantee th? company a top spot ?n th? front page ?f search engines, b?t ???? earns th? respect ?f clients, wh??h ??n translate t? revenues f?r th? business.

Reaching target clients ?n? increasing sales requires Online marketing strategies ??k? SEO. W?th th? aid ?f Internet marketing experts, a business need n?t stay stuck ?t th? bottom.

Click f?r further information ?n SEO ?r Website Design.. A??? published ?t Internet Marketing: Nothing Beats SEO.

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